Home Print this page Email this page Users Online: 165
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2023  |  Volume : 11  |  Issue : 2  |  Page : 92-96

An open-label randomized clinical trial to evaluate the efficacy and tolerability of flax seed nutritional supplementation in comparison with omega-3 fatty acid capsule in mild dry eye disease

1 Department of Ophthalmology, JGMM Medical College, Hubli, Karnataka, India
2 Department of Ophthalmology, JJM Medical College, Davangere, Karnataka, India

Correspondence Address:
Meghana Patil
Department of Ophthalmology, JGMM Medical College, Hubli - 580 024, Karnataka
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcor.jcor_24_23

Rights and Permissions

Background: Dry eye disease (DED) is a multifactorial disease commonly encountered in ophthalmology clinics. Omega-3 fatty acid has been proved to be effective in improving the symptoms of DED. Flax seed being the richest plant source of alpha-linolenic acid can be effective in DED. Aims: To evaluate the efficacy and tolerability of flax seed supplementation in comparison with omega-3 fatty acid capsules in DED. Setting and Design: Single-center randomized open-label clinical trial done at tertiary care hospital. Subjects and Methods: Two hundred sixty-eight subjects with clinically diagnosed mild dry eye received either flax seed supplementation daily for 3 months or omega-3 fatty acid capsule once daily for 3 months. Patients were evaluated at baseline, week 4, week 8, and week 12. On each visit subjects filled ocular surface disease index (OSDI) questionnaire and underwent Schirmer test, tear break up time (TBUT) and ocular staining. Results: One hundred thirty-three patients received flax seeds and 135 received omega-3 fatty acid. Schirmer test and TBUT showed increase in scores at each visit. OSDI scores reduced at subsequent visit and were statistically significant. Two factor repeated measures analyses of variances showed no statistically significant difference between the groups in terms of OSDI scores (P = 0.018). Conclusion: Our study demonstrated a rapid response to nutritional therapy (with flax seeds and omega-3 fatty acid capsules) in alleviating the signs and symptoms of dry eyes in both the groups. Flaxseeds supplementation is comparable to omega-3 fatty acid supplementation in DED and thus forms the cost-effective treatment for dry eyes and can be considered as an adjunctive therapy for the same.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded49    
    Comments [Add]    

Recommend this journal