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 Table of Contents  
REVIEW ARTICLE
Year : 2015  |  Volume : 3  |  Issue : 1  |  Page : 3-7

Long term ophthalmic sequelae of prematurity


Department of Ophthalmology, BPS Government Medical College for Women, Khanpur Kalan, Sonepat, Haryana, India

Date of Submission16-Feb-2014
Date of Acceptance28-Jul-2014
Date of Web Publication14-Jan-2015

Correspondence Address:
Keerti Mundey
Department of Ophthalmology, BPS Government Medical College for Women, Khanpur Kalan, Sonepat - 131 305, Haryana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2320-3897.149336

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  Abstract 

Survivors of preterm birth may present with various ocular conditions later in life. Long-term ophthalmic care in formerly preterm individuals is important as their vision may be compromised by sequelae of retinopathy of prematurity (ROP), refractive errors, strabismus, and cerebral vision impairment. They are also at risk of developing cataracts, angle closure glaucoma, and retinal detachment later in life. A protocol for follow up of preterm children with and without ROP at different ages needs to be established.

Keywords: Prematurity, arrested ocular growth, late sequelae, low vision


How to cite this article:
Mundey K, Chaudhry M, Sethi S. Long term ophthalmic sequelae of prematurity. J Clin Ophthalmol Res 2015;3:3-7

How to cite this URL:
Mundey K, Chaudhry M, Sethi S. Long term ophthalmic sequelae of prematurity. J Clin Ophthalmol Res [serial online] 2015 [cited 2021 Dec 4];3:3-7. Available from: https://www.jcor.in/text.asp?2015/3/1/3/149336

Ophthalmic problems are common among children born prematurely or with low birth weight. Retinopathy of prematurity (ROP), refractive error, strabismus, and cerebral vision impairment (CVI) are some of the conditions that can lead to visual impairment in preterm children. [1] Patients with an initial favorable outcome remain at an increased risk of ophthalmic pathologies later in life. [2] Epidemiologic studies suggest that suboptimal nourishment of fetus and/or infants may have long-term effects resulting in increased incidence of medical problems such as hypertension, obesity, diabetes, and cardiovascular disease. This is relevant to the adult outcome of very low birth weight (VLBW, <1500 g) infants. Individuals demonstrating rapid catch-up growth are considered to be at the greatest risk of medical complications. [3] In this context, further studies are needed to establish whether prematurity causes increased structural and functional vulnerability in ocular structures during postnatal expansion reflecting in increased incidence of ocular disorders due to involutive changes over time. The potentially devastating visual effects of ROP are well known, and this article aims to highlight other conditions associated with prematurity, which can adversely affect the visual potential in preterm children. At present, the need for regular ophthalmologic follow-up in formerly preterm individuals is not adequately recognized.


  Effects of Prematurity on the Eye Top


It is known that preterm birth affects normal retinal development and function. [4] Optical Coherence Tomography (OCT) studies have demonstrated that the total retinal thickness at the fovea is increased, and the foveal avascular zone is smaller in children born preterm than that of children born at term, regardless of the presence of ROP. [5] The foveal contour is abnormal with a shallow or absent foveal depression in infants born prematurely. [6] The relevance of these changes on vision is yet to be established.

The association of refractive errors with prematurity is well-documented. During the first months of life, preterm infants demonstrate more myopia, astigmatism, and anisometropia than full-term infants. In the neonatal period, preterm infants have mainly against the rule (ATR) astigmatic axes in contrast to with the rule (WTR) in full term infants. However, preterm infants usually lose their astigmatism or become WTR by six months corrected age. [7] In school-aged children with preterm birth, there is an increased incidence of myopia, hyperopia, and astigmatism. [8] Refractive errors at ten years of age are four times more common in those born preterm (29.6%) than in those born at term (7.8%). [9]

Preterm children are noted to have shallower anterior chamber depth (ACD), greater lens thickness (LT), and steeper central corneas as compared with age-matched control subjects. The presence of ROP is associated with considerably shorter ACD, thicker lens, and higher myopia and astigmatism. [8] It has been stated that whereas hyperopia is due to short axial length (AL), myopia in a formerly preterm child is mainly attributable to anterior segment components rather than to increased AL. However, in the same study, measurements of ocular components reveal that AL is longer in myopia of prematurity as compared to eyes with other refractive errors. [8] This implies that myopia of prematurity is mainly axial but AL appears to be relatively short as a steep cornea, shallow ACD, and a thicker lens also contribute towards the myopic error, as opposed to ordinary myopia, where these components tend to reduce the myopic error. [10]

Emmetropia is achieved in many premature children without ROP as a steep cornea and thick lens typical of a premature eye is compensated by a shorter AL. [11] Failure to emmetropise results in an increased incidence of not only myopia but all refractive errors. [7]

Cerebral visual impairment (CVI) is increasingly being recognized as a more common cause of visual impairment in preterm individuals than ROP. [12] In preterm infants, hypoxia selectively injures the periventricular deep white matter causing brain lesions known as periventricular leukomalacia (PVL). Since the optic radiations and the corticospinal motor tracts travel within the periventricular white matter, PVL is strongly associated with CVI. [13] The reported incidence of PVL ranges from 4-15% in most studies. [12] An Indian study found an incidence of 36.2% in a cohort of VLBW infants. [14] The presence and severity of periventricular brain damage may be more important than consideration of birth weight alone in extremely low birth weight (<1000 g) in predicting which preterm children will be at greatest risk for experiencing visuomotor problems at 6 years of age. [15]

Visual perception (VP), such as proper recognition of faces and forms, orientation, depth perception, and simultaneous perception, may be impaired in lesions of visual pathways causing disabling visual problems, but visual acuity (VA) might be spared in spite of extensive lesions as fibers from the macula are widely distributed in the visual pathways, leading to the visual problems of affected children being either unrecognized or underappreciated. A population based study on Swedish schoolchildren born at less than 29 weeks gestation found an incidence of visual impairment (VA less than 6/18) in 6% but subnormal VP was detected in 42%. Children with perceptual problems caused by CVI are often considered to have learning disabilities (mental retardation) in spite of their normal intelligence. A better understanding of the child's problems by parents and teachers results in a better approach to help the affected child. [12] Some difficulties related to prematurity may disappear with age. In a study of teenagers born preterm, periventricular white matter lesions were found to be common, but teenagers with these lesions did not differ in neuropsychological outcomes from those without such lesions. [16]

Visual field defects, usually affecting the lower field, have been reported in premature children with visual impairment due to white matter damage of immaturity (WMDI) also known as periventricular leukomalacia (PVL). [17] Other studies did not find visual field defects in premature children as compared with control subjects, except for peripheral field defects in children who had received cryotherapy. [18] However, early treatment, i.e., retinal ablation administered to the avascular retina when an eye reaches high-risk prethreshold ROP, preserves peripheral vision and does not adversely affect visual field extent clinically. [19] Visual field studies done using static high-pass resolution perimetry reveal a tendency towards defects of the central visual fields that are unrelated to ROP and cryotherapy. [18]

Incidence of strabismus is increased in children born prematurely. This has been associated with retinopathy of prematurity, low birth weight, cerebral palsy, anisometropia, and refractive error. [20] At one year follow up of preterm Asian children, strabismus was found in 20% in the ROP group compared to 4.9% in the no ROP group. [21] A population-based study in preterm Nordic children born with a birth weight of 1500 g or less, found that over the first 42 months of life (corrected age), the incidence of strabismus among children without a history of ROP or neurological complications was 5.9% as compared to 22% among the children with ROP or neurological complications, with an overall incidence of 13.5%. [22] Amongst ten-year-old children, strabismus was noted in 16.2% premature and in 3.2% full-term children. [23]

It is postulated that the etiology of strabismus in preterms may differ from that of full terms as the ratio of esotropia: exotropia is 1: 1 in the low-birth weight population as compared to 3:1 in full-term children, and the incidence of near exotropia, a relatively uncommon type of strabismus, is 12%. [1]

Preterm birth results in major changes in the fetal milieu which may interfere with the early development of the lenses and result in cataract in both eyes, as suggested by the increased risk (10.6 times) of bilateral cataract in children with birth weight <2000 g as compared to children with a birth weight of 3000-3500 g. [24] Another study done on premature children within twelve months of life confirms that LBW (1500-2499 g) is strongly associated with bilateral cataracts but made the additional observation that VLBW (<1500 g) is associated with both unilateral and bilateral cataracts. [25] In adults with a history of preterm birth and low birth weight, cataract surgery tends to be performed at a younger age (mean 40.3 years) but improvement in vision is suboptimal. The risk of retinal tear or detachment is high (23%) following cataract surgery. [26]

Glaucoma is also a known complication of prematurity. The glaucoma described in ROP is usually associated with a narrow anterior angle with a shallow anterior chamber and a retrolental membrane or a swollen lens pushing the iris-lens diaphragm forward. [27] The Cryotherapy for Retinopathy of Prematurity Cooperative Group (CRYO-ROP) study determined that in children with bilateral threshold ROP, the incidence of glaucoma at the 5.5 year examination was 2.9% in treated eyes and 6.1% in control eyes, [28] while the Early Treatment for Retinopathy of Prematurity (ET-ROP) study found that nearly 2% of eyes with high-risk prethreshold ROP developed glaucoma at some point during the first 6 years of life. [27]

In adults with regressed ROP, angle closure glaucoma may occur due to relative anterior microphthalmos consequent to arrested development of the anterior segment. Shallowing of the anterior chamber and risk of development of angle-closure glaucoma increases with age, usually manifesting during or after the third decade of life. A detailed history and consideration of the biometric data is important for diagnosis. [29] In some cases, a jammed anterior segment due to arrested development leads to severe glaucoma and a painful blind eye. [2]

It is generally believed that the occurrence of myopia in angle closure is rare; however, a recent study has revealed the presence of myopia in 22% East Asian patients with primary angle closure. These patients with angle closure have predominantly axial myopia, but the ACD is similar to those of hyperopes and emmetropes. This suggests that ACD is an important risk factor in the development of angle closure, regardless of AL or refractive status. While a multifactorial cause for angle closure in these myopes is probable, the configuration of the anterior segment may predispose them to angle closure. [30] This study raises the question as to whether myopia of prematurity (MOP) increases the risk of angle closure even in preterm individuals without ROP, due to arrested development of anterior segment manifesting in a shallow ACD and a thick lens, though the arrest is much less as compared to eyes with regressed ROP.

Formerly preterm children also have reduced distance and near visual acuity as compared with full-term children, even when children with ROP and neurological disorders are excluded. [31] It has been speculated that cone damage may occur following prolonged exposure to illumination such as during treatment for jaundice. Intrauterine infections are a common cause of preterm labor and prenatal endotoxin exposure may be harmful to the developing retina and optic nerve. [1]

Prematurely born children have significantly lower contrast sensitivity (CS) in the low- and mid-range spatial frequencies. Contrast sensitivity estimates the ability to detect daily life objects, which may explain visual problems in preterm children despite a normal VA. [32] Deficits in CS vision in low birth weight children persists even in the absence of ROP or known neurological abnormalities. [33]

Children with regressed ROP are more vulnerable to vitreoretinal complications such as retinal tears, retinal detachment (RD), and vitreous hemorrhage in the long term. It is postulated that some preterm eyes with a poorly vascularized retina may be unable to tolerate trauma, disease, or the changes associated with aging. Retinal tears may be due to the failure of a scarred retina to expand along with the postnatal expansion of the eyeball. [2] The retinal holes are characteristically multiple with a prevalence of equator and posterior types. [34] Late RD is the main vision-threatening condition in patients with regressed ROP during childhood. [35] Lifelong follow up of high risk patients is probably necessary so that early diagnosis and treatment can be instituted. [34]

The CRYO-ROP study found that in preterm children with birth weights less than 1251 g and severe (threshold) retinopathy of prematurity (ROP) in one or both eyes, there was a gradual increase in unfavorable structural outcomes between the 1-year and 15-year outcome assessments. Between 10 and 15 years of age, new retinal folds, detachments, or obscuring of the view of the posterior pole occurred in 4.5% of treated and 7.7% of control eyes. In treated eyes, unfavorable outcomes averaged 0.35% per year, while control eyes averaged 0.51% per year. [36]

A recent population-based cohort study has found that, between 1987 and 2008, individuals born at <28 weeks gestation have a nine-fold increase in the risk of RD while those born at 28-31 weeks gestation have a 3 times higher increase in risk as compared to peers born at term. Preterm birth at 32-36 weeks of gestation was not found to be associated with an increased risk of RD. [37]

As is evident from above discussion, there is a greatly increased risk of ophthalmic deficits in preterm children with severe ROP or severe neurological disorders and in those with mild or no ROP. Children in the latter group are not routinely followed up. There is no standardized approach for the ophthalmic care follow up of children screened for retinopathy of prematurity (ROP). [38] At present, even in developed countries, follow up of preterm infants is haphazard. [39] A survey of existing ophthalmic follow up protocols in the United Kingdom (UK) for VLBW children found a large variation in criteria used for follow up; 21% of respondents using birth weight (BW) and gestational age (GA), 22% using stage 3 or treated ROP, the remainder considering a combination of these factors. There was no consensus regarding when follow up should commence (from 3 months to 3 years) or cease (1-8 years). [38]

In countries where preventive child healthcare is well organized, such as Sweden, ophthalmological screening of children is done mainly to detect refractive errors and strabismus. [40] However, apart from these conditions, preterm children, especially with regressed ROP, are at increased risk for glaucoma, retinal detachment, and defects in visual perception. These conditions require detailed examination and are likely to be missed at routine screenings under preventive child health care programs.

Long-term effects of prematurity in individuals who have reached early adulthood without any diagnosed ophthalmic problem remains largely unknown. More studies are needed on preterm children to determine the schedule, method of assessment, and duration of follow up examinations. Multiple protocols will probably be needed, which will vary based upon the presence or absence of ROP, severity of ROP, birth weight, gestational age, and presence of CVI. The CRYO-ROP study recommends that it is of value to have long-term, regular follow up of eyes with threshold ROP. [35] The question as to whether ophthalmologic follow up should be continued well into adulthood needs to be clarified by future studies.


  Conclusion Top


Adverse ophthalmic sequelae of prematurity may manifest later in life. It is recommended that all preterm infants with a gestational age less than 32 weeks should be screened at the age of one year, in the third year of life, and just before school age for the detection of refractive errors, amblyopia, and strabismus. [41] A comprehensive follow-up, which includes fundus examination and tests of visual perception, is also necessary and a protocol needs to be formulated for it. Parents should be counseled that even preterm infants with a favorable primary outcome should have regular ocular examinations throughout childhood and beyond.

 
  References Top

1.
O'Connor AR, Wilson CM, Fielder AR. Ophthalmological problems associated with preterm birth. Eye (Lond) 2007;21:1254-60.  Back to cited text no. 1
    
2.
Fledelius HC, Jensen H. Late subsequent ocular morbidity in retinopathy of prematurity patients, with emphasis on visual loss caused by insidious 'involutive' pathology: An observational series. Acta Ophthalmol 2011;89:316-23.  Back to cited text no. 2
    
3.
Hack M. Young adult outcomes of very-low-birth-weight children. Semin Fetal Neonatal Med 2006;11:127-37.   Back to cited text no. 3
    
4.
Park KA, Oh SY. Analysis of spectral-domain optical coherence tomography in preterm children: Retinal layer thickness and choroidal thickness profiles. Invest Ophthalmol Vis Sci 2012;53:7201-7.  Back to cited text no. 4
    
5.
Yanni SE, Wang J, Chan M, Carroll J, Farsiu S, Leffler JN, et al. Foveal avascular zone and foveal pit formation after preterm birth. Br J Ophthalmol 2012;96:961-6.  Back to cited text no. 5
    
6.
Recchia FM, Recchia CC. Foveal dysplasia evident by optical coherence tomography in patients with a history of retinopathy of prematurity. Retina 2007;27:1221-6.  Back to cited text no. 6
    
7.
Saunders KJ, McCulloch DL, Shepherd AJ, Wilkinson AG. Emmetropisation following preterm birth. Br J Ophthalmol 2002;86:1035-40.  Back to cited text no. 7
    
8.
Chen TC, Tsai TH, Shih YF, Yeh PT, Yang CH, Hu FC, et al. Long-term evaluation of refractive status and optical components in eyes of children born prematurely. Invest Ophthalmol Vis Sci 2010;51:6140-8.  Back to cited text no. 8
    
9.
Larsson EK, Rydberg AC, Holmström GE. A population-based study of the refractive outcome in 10-year-old preterm and full-term children. Arch Ophthalmol 2003;121:1430-6.  Back to cited text no. 9
    
10.
Fledelius HC. Retinopathy and myopia of prematurity. Br J Ophthalmol 2000;84:937.   Back to cited text no. 10
    
11.
Kaur S, Daud NM, Meng CK, Ariffin AE, Nemyun B, Choo OL. Refractive and biometric status of children born premature without retinopathy of prematurity. Sains Malaysiana 2010;39:859-62.  Back to cited text no. 11
    
12.
Hård AL, Niklasson A, Svensson E, Hellström A. Visual function in school-aged children born before 29 weeks of gestation: A population-based study. Dev Med Child Neurol 2000;42:100-5.  Back to cited text no. 12
    
13.
Kozeis N. Brain visual impairment in childhood: Mini review. Hippokratia 2010;14:249-51.  Back to cited text no. 13
    
14.
Maria A, Gupta A, Aggarwal R, Sreenivas V, Paul VK, Deorari AK. Incidence of periventricular leucomalacia among a cohort of very low birth weight neonates(< 1500 g). Indian Pediatr 2006;43:210-6.  Back to cited text no. 14
    
15.
Jakobson LS, Frisk V, Knight RM, Downie AL, Whyte H. The relationship between periventricular brain injury and deficits in visual processing among extremely-low-birthweight (<1000 g) children. J Pediatr Psychol 2001;26:503-12.   Back to cited text no. 15
    
16.
Rushe TM, Rifkin L, Stewart AL, Townsend JP, Roth SC, Wyatt JS, et al. Neuropsychological outcome at adolescence of very preterm birth and its relation to brain structure. Dev Med Child Neurol 2001;43:226-33.  Back to cited text no. 16
    
17.
Jacobson L, Flodmark O, Martin L. Visual field defects in prematurely born patients with white matter damage of immaturity: A multiple-case study. Acta Ophthalmol Scand 2006;84:357-62.  Back to cited text no. 17
    
18.
Lindqvist S, Vik T, Indredavik MS, Brubakk AM. Visual acuity, contrast sensitivity, peripheral vision and refraction in low birthweight teenagers. Acta Ophthalmol Scand 2007;85:157-164.   Back to cited text no. 18
    
19.
Quinn GE, Dobson V, Hardy RJ, Tung B, Palmer EA, Good WV; Early Treatment for Retinopathy of Prematurity Cooperative Group. Visual field extent at 6 years of age in children who had high-risk prethreshold retinopathy of prematurity. Arch Ophthalmol 2011;129:127-32.  Back to cited text no. 19
    
20.
O'Connor AR, Stephenson TJ, Johnson A, Tobin MJ, Ratib S, Fielder AR. Strabismus in children of birth weight less than 1701 g. Arch Ophthalmol 2002;120:767-73.  Back to cited text no. 20
    
21.
Theng JT, Wong TY, Ling Y. Refractive errors and strabismus in premature Asian infants with and without retinopathy of prematurity. Singapore Med J 2000;41:393-7.  Back to cited text no. 21
    
22.
Holmström G, el Azazi M, Kugelberg U. Ophthalmological follow up of preterm infants: A population based prospective study of visual acuity and strabismus. Br J Ophthalmol 1999;83:143-50.   Back to cited text no. 22
    
23.
Holmström G, Rydberg AC, Larsson EK. Prevalence and development of strabismus in 10-year-old premature children: A population-based study. J Pediatr Ophthalmol Strabismus 2006;43:346-52.   Back to cited text no. 23
    
24.
Haargaard B, Wohlfahrt J, Rosenberg T, Fledelius HC, Melbye M. Risk Factors for Idiopathic Congenital/Infantile Cataract. Invest Ophthalmol Vis Sci 2005;46:3067-73.  Back to cited text no. 24
    
25.
Prakalapakorn SG, Rasmussen SA, Lambert SR, Honein MA, National Birth Defects Prevention Study. Assessment of risk factors for infantile cataracts using a case-control study: National Birth Defects Prevention study, 2000-2004. Ophthalmology 2010;117:1500-5.  Back to cited text no. 25
    
26.
Kaiser RS, Fenton GL, Tasman W, Trese MT. Adult retinopathy of prematurity: Retinal complications from cataract surgery. Am J Ophthalmol 2008;145:729-35.  Back to cited text no. 26
    
27.
Bremer DL, Rogers DL, Good WV, Tung B, Hardy RJ, Fellows R. Glaucoma in the early treatment for retinopathy of prematurity (ETROP) study. J AAPOS 2012;16:449-52.  Back to cited text no. 27
    
28.
Cryotherapy for Retinopathy of Prematurity Cooperative Group. Multicenter trial of cryotherapy for retinopathy of prematurity. Snellen visual acuity and structural outcome at 5 1/2 years after randomization. Arch Ophthalmol 1996;114:417-24.  Back to cited text no. 28
    
29.
Ziemssen F, Adam H, Bartz-Schmidt KU, Schlote T. Angle closure glaucoma in association with relative anterior microphthalmus (RAM) after premature birth-retinopathy (ROP). Klin Monbl Augenheilkd 2004;221:503-8.  Back to cited text no. 29
    
30.
Yong KL, Gong T, Nongpiur ME, How AC, Lee HK, Cheng L, et al. Myopia in asian subjects with primary angle closure: Implications for glaucoma trends in east Asia. Ophthalmology 2014;121:1566-71.  Back to cited text no. 30
    
31.
Larsson EK, Rydberg AC, Holmström G. A population-based study on the visual outcome in 10-year-old preterm and full-term children. Arch Ophthalmol 2005;123:825-32.  Back to cited text no. 31
    
32.
Larsson EK, Rydberg AC, Holmström G. Contrast sensitivity in 10 year old preterm and full term children: A population based study. Br J Ophthalmol 2006;90:87-90.  Back to cited text no. 32
    
33.
Dowdeswell HJ, Slater AM, Broomhall J, Tripp J. Visual deficits in children born at less than 32 weeks' gestation with and without major ocular pathology and cerebral damage. Br J Ophthalmol 1995;79:447-52.  Back to cited text no. 33
    
34.
Terasaki H, Hirose T. Late-onset retinal detachment associated with regressed retinopathy of prematurity. Jpn J Ophthalmol 2003;47:492-7.  Back to cited text no. 34
    
35.
Park KH, Hwang JM, Choi MY, Yu YS, Chung H. Retinal detachment of regressed retinopathy of prematurity in children aged 2 to 15 years. Retina 2004;24:368-75.  Back to cited text no. 35
    
36.
Palmer EA, Hardy RJ, Dobson V, Phelps DL, Quinn GE, Summers CG, et al. Cryotherapy for Retinopathy of Prematurity Cooperative Group. 15 year outcomes following threshold retinopathy of prematurity: Final results from the multicentre trial of cryotherapy for retinopathy of prematurity. Arch Ophthalmol 2005;123:311-8.  Back to cited text no. 36
    
37.
Bonamy AK, Holmström G, Stephansson O, Ludvigsson JF, Cnattingius S. Preterm birth and later retinal detachment: A population-based cohort study of more than 3 million children and young adults. Ophthalmology 2013;120:2278-85.   Back to cited text no. 37
    
38.
O'Connor AR, Stewart CE, Singh J, Fielder AR. Do infants of birth weight less than 1500 g require additional long term ophthalmic follow up? Br J Ophthalmol 2006;90:451-5.  Back to cited text no. 38
    
39.
O'Connor A, Fielder AR. Long term ophthalmic sequelae of prematurity. Early Hum Dev 2008;84:101-6.   Back to cited text no. 39
    
40.
Hård AL, Hellström A. Ophthalmological follow-up at 2 years of age of all children previously screened for retinopathy of prematurity: Is it worthwhile? Acta Ophthalmol Scand 2006;84:631-5.  Back to cited text no. 40
    
41.
Schalij-Delfos NE, de Graaf ME, TreVers WF, Engel J, Cats BP. Long term follow up of premature infants: Detection of strabismus, amblyopia, and refractive errors. Br J Ophthalmol 2000;84:963-7.  Back to cited text no. 41
    



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