Home Print this page Email this page Users Online: 229
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 


 
 Table of Contents  
BRIEF COMMUNICATION
Year : 2019  |  Volume : 7  |  Issue : 2  |  Page : 78-81

Inadvertent descemetorhexis and Descemet's membrane detachment after cataract surgery – Reendothelialization after C3F8 descemetopexy: A case report and review of literature


Cornea Services, Chaithanya Eye Hospital and Research Institute, Trivandrum, Kerala, India

Date of Submission01-Mar-2018
Date of Acceptance04-Sep-2018
Date of Web Publication21-Aug-2019

Correspondence Address:
Abraham Kurian
Medical Superintendent and Senior Consultant, Chaithanya Eye Hospital and Research Institute, Kesavadasapuram, Trivandrum - 695 004, Kerala
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcor.jcor_29_18

Rights and Permissions
  Abstract 

We report a case of extracapsular cataract surgery, wherein inadvertent large central descemetorhexis and loss of Descemetís membrane (DM) were noted intraoperatively. Postoperatively, near total detachment of the remaining DM was noted. C3F8 descemetopexy at 2 weeks resulted in successful reattachment of the detached DM and reendothelialization in the area of lost DM. The corneal edema resolved with eventual good visual outcome and no complications. Although spontaneous reattachment of Descemetís detachment is described, early descemetopexy results in better visual outcome even in cases with extensive DM loss probably due to early resumption of the physiologic function following earlier anatomic reattachment.

Keywords: C3F8, descemetopexy, descemetorhexis


How to cite this article:
Kurian A, Reghunadhan I, Nair S, George A. Inadvertent descemetorhexis and Descemet's membrane detachment after cataract surgery – Reendothelialization after C3F8 descemetopexy: A case report and review of literature. J Clin Ophthalmol Res 2019;7:78-81

How to cite this URL:
Kurian A, Reghunadhan I, Nair S, George A. Inadvertent descemetorhexis and Descemet's membrane detachment after cataract surgery – Reendothelialization after C3F8 descemetopexy: A case report and review of literature. J Clin Ophthalmol Res [serial online] 2019 [cited 2019 Sep 21];7:78-81. Available from: http://www.jcor.in/text.asp?2019/7/2/78/264891



Descemet's membrane (DM) detachment is a rare but well-recognized complication of cataract surgery. Reports of iatrogenic descemetorhexis are few. Even cases with complicated DM detachments with large areas of central DM loss, when managed with early descemetopexy, can have successful reendothelialization and regain acceptable endothelial function and corneal clarity.


  Case Report Top


A 73-year-old female patient, with mature cataract in her right eye and preoperative vision of hand movements, underwent extracapsular cataract surgery by a resident. After a superior section and dye-assisted capsulotomy, hydrodissection was attempted. The senior trained surgeon suspected an inadvertent descemetorhexis, took over and completed the rest of the surgery uneventfully. Intraoperatively, there was no overt evidence of detached DM and no active intervention was done.

During immediate postoperative period, the eye had full-thickness corneal edema and vision 1/60. A faint demarcation line inferiorly suggested a DM loss. Specular microscopy did not reveal any discernible endothelial cells (ECs). Hypertonic saline and lubricants were added to routine postoperative topical medications.

Anterior segment optical coherence tomography (ASOCT) 2 weeks postoperatively showed a central area of DM loss and the surrounding residual DM detached [Figure 1]a.
Figure 1: (a) Anterior segment optical coherence tomography, 2 weeks after cataract surgery, showing corneal edema with central area of Descemet's membrane loss and the residual Descemet's membrane detached to varying extents along the surrounding periphery. (b) Anterior segment optical coherence tomography, 2 months postdescemetopexy, showing the residual Descemet's membrane attached. Superior cornea showing some residual edema with a thickened posterior corneal layer

Click here to view


The patient underwent descemetopexy with 14% C3F8 the same day. The corneal edema started clearing from the next day and by 5th day vision improved to 6/18.

Two weeks postinjection, the inferior border of the central DM loss could clearly be delineated, but the partially absorbed gas bubble and residual sectional edema obscured the superior border [Figure 2]a. Specular microscopy showed central EC density (ECD) of 580/mm2 with 0% hexagonality. Specular microscopy of the pseudophakic fellow eye showed ECD of 1860/mm2 and 40% hexagonality.
Figure 2: (a) 2 weeks postdescemetopexy, the cornea showing significant clearing, the inferior border of the central area of Descemet's membrane loss clearly seen (superior border obscured by gas bubble and sectional edema). (b) 2 months postdescemetopexy, clear central cornea with clearly defined margins of the Descemet's loss seen extending to the superior limbus

Click here to view


Two months postoperatively, the gas bubble absorbed and the best-corrected vision improved to 6/6. The clear central cornea showed the well-delineated margins of the DM loss which measured 7.5 mm × 6 mm and extended to the superior limbus at the incision site [Figure 2]b. ASOCT now showed the remaining DM attached to the posterior stroma surrounding the areas of DM loss. However, the superior cornea near the section showed some residual edema with a thickened posterior corneal layer [Figure 1]b.

Repeat specular microscopy of the central cornea showed increase in ECD to 1668/mm2 with polymorphism and polymegathism but 0% hexagonality. However, specular microscopy done in the superior area corresponding to the thickened posterior corneal layer showed ECD of 811/mm2 and 0% hexagonality.


  Discussion Top


Human corneal endothelium is characterized by a low regenerative capacity, attributed to low mitotic activity, and therefore, complete regeneration of the endothelial layer after injury is precluded.[1] Interest in migration and enlargement capacities of ECs has been renewed due to recent breakthroughs in endothelial keratoplasty.

Study by Schwartzkopff et al.[2] in a rat keratoplasty model concluded that reendothelialization following keratoplasty occursin vivo and restores graft clarity, following both immunological or surgical destruction of ECs. The study also provided evidence that peripheral recipient ECs are a sufficient source for graft reendothelialization.

Similar concepts have been speculated by Balachandran et al.,[3] who reported spontaneous recovery of corneal transparency in two cases with nearly complete graft detachment after Descemet membrane endothelial keratoplasty.

Although these dealt with EC loss in keratoplasty, the same concept holds true in descemetorhexis, and hence, these postulates on endothelial regeneration can be extrapolated to our case.

DM detachment is a rare but well-recognized complication of cataract surgery with a reported incidence of 0.5%–2.6%.

There is a relative paucity in literature regarding the guidelines for the management of DM detachment.

There are reports of resolution of prolonged corneal edema after spontaneous reattachment,[4] but it takes several weeks to months. Meanwhile prolonged corneal edema may lead to visually significant corneal opacification.[4] Waiting for spontaneous reattachment carries the risk of possible permanent corneal opacification and eventual keratoplasty for optimal vision.

Chow et al.,[5] in 2013, state that DM detachments may be treated either conservatively or surgically, with early surgical intervention favored for scrolled, extensive detachments. They conclude that optimal timing and treatment remain an unexplored area. Despite several reports of spontaneous DM reattachment, early intervention is advocated for speedy and best visual recovery. A study by Jain et al.[6] on descemetopexy in postcataract surgery DM detachment concludes that early intervention by descemetopexy has a good final outcome.

There have been nine case reports[7] published till date on iatrogenic descemetorhexis [Table 1]. Intracameral air injection was done in 2 eyes and 1 required intracameral air and SF6 injection along with transcorneal suturing. Of the rest which were managed conservatively, spontaneous resolution took several weeks to months and the final vision was much less compared to our case which regained a normal visual acuity in 2 months.
Table 1: Case reports on inadvertent descemetorhexis published till date

Click here to view


Although the area of DM loss in those case reports was much smaller (about 5 mm × 5 mm) compared to 7.5 mm × 6 mm in our case, the final visual improvement was grossly subnormal compared to our case. Those cases with larger areas of DM loss had a grossly inadequate gain in vision.

To the best of our knowledge, ours is the first report of DM detachment complicated by descemetorhexis successfully managed by early C3F8 descemetopexy.


  Conclusion Top


Supporting evidence from studies shows that migration and proliferation of the existing cells in the periphery can help in restoring the corneal clarity. To aid an earlier reattachment of DM detachment, the use of intracameral C3F8 is a safe and accepted procedure and should be tried as the first option even in cases complicated by loss of DM.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

All authors have completed and submitted the ICMJE Form for the Disclosure of Potential Conflicts of Interest, and none were reported.



 
  References Top

1.
Joyce NC, Meklir B, Joyce SJ, Zieske JD. Cell cycle protein expression and proliferative status in human corneal cells. Invest Ophthalmol Vis Sci 1996;37:645-55.  Back to cited text no. 1
    
2.
Schwartzkopff J, Bredow L, Mahlenbrey S, Boehringer D, Reinhard T. Regeneration of corneal endothelium following complete endothelial cell loss in rat keratoplasty. Mol Vis 2010;16:2368-75.  Back to cited text no. 2
    
3.
Balachandran C, Ham L, Verschoor CA, Ong TS, van der Wees J, Melles GR, et al. Spontaneous corneal clearance despite graft detachment in descemet membrane endothelial keratoplasty. Am J Ophthalmol 2009;148:227-340.  Back to cited text no. 3
    
4.
Marcon AS, Rapuano CJ, Jones MR, Laibson PR, Cohen EJ. Descemet's membrane detachment after cataract surgery: Management and outcome. Ophthalmology 2002;109:2325-30.  Back to cited text no. 4
    
5.
Chow VW, Agarwal T, Vajpayee RB, Jhanji V. Update on diagnosis and management of descemet's membrane detachment. Curr Opin Ophthalmol 2013;24:356-61.  Back to cited text no. 5
    
6.
Jain R, Murthy SI, Basu S, Ali MH, Sangwan VS. Anatomic and visual outcomes of descemetopexy in post-cataract surgery descemet's membrane detachment. Ophthalmology 2013;120:1366-72.  Back to cited text no. 6
    
7.
Jullienne R, Manoli P, Tiffet T, He Z, Rannou K, Thuret G, et al. Corneal endothelium self-healing mathematical model after inadvertent descemetorhexis. J Cataract Refract Surg 2015;41:2313-8.  Back to cited text no. 7
    


    Figures

  [Figure 1], [Figure 2]
 
 
    Tables

  [Table 1]



 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
Abstract
Case Report
Discussion
Conclusion
References
Article Figures
Article Tables

 Article Access Statistics
    Viewed41    
    Printed0    
    Emailed0    
    PDF Downloaded15    
    Comments [Add]    

Recommend this journal