Home Print this page Email this page Users Online: 202
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 


 
 Table of Contents  
BRIEF COMMUNICATION
Year : 2019  |  Volume : 7  |  Issue : 1  |  Page : 24-26

Keratoactinomycosis: A rare case report


Department of Ophthalmology, M and J Western Regional Institute of Ophthalmology, Ahmedabad, Gujarat, India

Date of Submission17-Mar-2018
Date of Acceptance22-Aug-2018
Date of Web Publication12-Mar-2019

Correspondence Address:
Pradnya Krishnakant Bhole
Department of Ophthalmology, M and J Western Regional Institute of Ophthalmology, B J Medical College Campus, C/34, Sanjay Tower, Shyamal Cross Roads, Ahmedabad - 380 015, Gujarat
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jcor.jcor_3_18

Rights and Permissions
  Abstract 


A 50-year-old female farmer, with a history of vegetative trauma, presented to a tertiary eye care center, with right eye ulcerative keratitis, initially treated elsewhere as fungal keratitis, refractory to conventional antifungal therapy. A corneal scraping was done and it revealed Gram-positive filamentous Actinomyces bacteria. Treatment with topical penicillin (100,000 U/ml) showed a complete resolution of the corneal infection, within 2 weeks of therapy. Actinomyces keratitis is a rare clinical condition. A history of ocular vegetative trauma, with a clinical picture similar to fungal keratitis, leads to delay in the diagnosis of such rare presentations of posttraumatic keratoactinomycosis, which otherwise shows a good response to topical penicillin therapy. A corneal scraping done helps in timely diagnosis and effective treatment.

Keywords: Keratoactinomycosis, penicillin, scraping


How to cite this article:
Bhole PK, Parmar DP. Keratoactinomycosis: A rare case report. J Clin Ophthalmol Res 2019;7:24-6

How to cite this URL:
Bhole PK, Parmar DP. Keratoactinomycosis: A rare case report. J Clin Ophthalmol Res [serial online] 2019 [cited 2019 Mar 21];7:24-6. Available from: http://www.jcor.in/text.asp?2019/7/1/24/253989



Actinomycetes are true Gram-positive bacteria; they are anaerobic nonsporing, noncapsulated, non acid-fast filaments that bear superficial resemblance to fungi. Most are free living, particularly in the soil.[1] Actinomycetes have been reported as a causative organisms of eye infection in keratitis, canaliculitis (Actinomyces israelii), conjunctivitis, blepharitis, postsurgical endophthalmitis, and porous orbital implant infection.[2]

Actinomycosis is a rare cause of ulcerative keratitis. A primary corneal ulcer attributed to Actinomyces species usually follows corneal trauma.[2] Actinomyces keratitis typically presents as a dry-looking ulcer with necrotic bed, surrounded by a yellow demarcating gutter. The ulcer tends to progress slowly, but ultimately necrosis may lead to descematocoele, followed by perforation. Associated inflammation can be severe with iritis and hypopyon.[3] Actinomycetes are usually susceptible to penicillins and cephalosporins. Prognosis is good, once the organism is positively identified and appropriately treated. Hence, an immediate identification of the organism is essential to institute timely appropriate treatment and avoid a surgical intervention.[4]

A few cases of actinomyces keratitis, with variable outcomes, have been reported in the scientific literature. We report a rare case of posttraumatic keratoactinomycosis with a good response to topical penicillin therapy.


  Case Report Top


A 50-year-old female farmer presented with pain, redness, discharge, watering, photophobia, and diminished vision in the right eye (RE), for 10 days, following vegetative trauma. She was diagnosed elsewhere as fungal keratitis, based on clinical suspicion and was started on natamycin 5% eye drops 1 hourly, with topical cycloplegics and oral fluconazole. She showed no improvement with the treatment.

Visual acuity in the RE at presentation was HM + PL + PR4+ and the left eye (LE) had 6/9 with spectacle correction. On slit-lamp biomicroscopy examination of RE, lid edema and purulent discharge were noted. This was associated with diffuse and circumcorneal congestion and follicular papillary response in the palpebral conjunctiva. A dry-looking corneal ulcer, approximately 4 mm × 3 mm, with deep stromal infiltration in its bed was noted. Peripheral corneal vascularization involving almost the entire circumference of cornea was noted. The limbal tissue adjacent to the ulcer was markedly inflamed. The anterior chamber was of normal depth with associated marked iritis and hypopyon of approximately 1.5 mm. The pupil was semidilated and not reacting to light (under the effect of topical cycloplegic) and pseudophakia was present [Figure 1]. LE was found to be normal. Ultrasonography of the affected eye and a complete blood count with blood sugar levels were found to be normal.
Figure 1: Clinical presentation – Corneal ulcer with stromal infiltration with adjoining limbal inflammation

Click here to view


A corneal scraping, under aseptic precautions, from the edges and the bed of the ulcer was done and subjected to 10% potassium hydroxide wet mount and Gram staining. The corneal scraping report revealed Gram-positive filamentous bacteria, namely Actinomyces [Figure 2] and [Figure 3].
Figure 2: Actinomyces – Gram-positive filamentous rods

Click here to view
Figure 3: Actinomyces – Sulfur granules

Click here to view


Depending upon the microbiological report, the patient was started on topical penicillin eye drops (100,000 U/ml) along with topical preservative-free artificial tear substitutes and cycloplegic drops. This was accompanied by systemic oral administration of a combination of 500 mg amoxicillin and 125 mg clavulanic acid twice a day for 5 days and analgesic anti-inflammatory tablets.

The patient responded well to this treatment and showed a decrease in the infiltration within 48–72 h of the start of treatment. The size of the ulcer started reducing with a resolution of hypopyon in around 1 week. The ulcer resolved with scar formation within 2 weeks of the start of treatment [Figure 4] and [Figure 5].
Figure 4: At 5 days – Decrease in the size of corneal ulcer with resolution of iritis and hypopyon

Click here to view
Figure 5: At 15 days – healed keratitis

Click here to view



  Discussion Top


Few cases of actinomyces keratitis have been reported in the literature till date. In a case reported in 1989 by Singh M and Kaur B in Malaysia, actinomyces keratitis developed in the absence of any known ocular trauma. It showed a dramatic response to penicillin therapy.[3]

Another case reported in 2008 by Karimian et al. in Iran had unilateral A. israelii keratitis in the corneal interface, 5 months after laser in situ keratomileusis, which responded well to topical antibiotics.[4]

In 2009, two cases reported by Andrés Emanuelli et al. in Puerto Rico had a history of vegetative trauma and a presentation of over 1 week after the trauma, suggesting the slow growth of Actinomyces, similar to fungal keratitis. Patients were misdiagnosed as fungal keratitis until cultures suggestive of Actinomyces were available. Delay in diagnosis and initiation of the appropriate treatment lead to the need of penetrating keratoplasty in both the cases.[5]

In our case report too, an initial antifungal therapy was started elsewhere, on suspicion of fungal keratitis, but it proved ineffective. Only after the patient presented to our center, and after the scraping report revealed Actinomyces, did the patient respond favorably to the specific penicillin therapy.

Clinically, actinomyces keratitis may resemble nocardia keratitis and it should also be considered in the differential diagnosis, although it presents predominantly with anterior stromal infiltrates.

Even in clinical situations of doubt, microbiological investigation helps to confirm the diagnosis. A corneal scraping smear showing beaded Gram-positive partially acid-fast branching filaments is highly suggestive of nocardia. Actinomyces is nonacid fast.[6]

We report this case to alert the clinician of an uncommon cause of ulcerative keratitis that can be destructive, if treatment is delayed, but seems to be responsive to appropriate and timely diagnosis by corneal scraping guiding proper treatment and also to highlight the importance of a good microbiological setup for accurate diagnosis.

Actinomyces should be suspected in the presence of slow-growing posttraumatic corneal ulcers with fungal resemblance, in the absence of positive cultures, and in the patient who is not responding to antifungal therapy as expected. Once the diagnosis is made, treatment is effective with topical and systemic penicillin or cephalosporins.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given her consent fpr her images and other clinical information to be reported in the journal. The patient understands that her name and initials will not be published and due efforts will be made to conceal her identity, but anonymity cannot be gauranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Ananthanarayan R, Paniker CK. Ananthanarayan and Paniker's Textbook of Microbiology. 8th ed. Universities Press, Hyderabad 2009; p. 391-4.  Back to cited text no. 1
    
2.
Emanuelli A, Tous H, Amaral C, Rivera L. Actinomyces species a rare cause of keratitis: Case series and literature review. Vision Pan Am 2009;8:219-21.  Back to cited text no. 2
    
3.
Yanoff M, Duker J. Ophthalmology. 4th ed. Elsevier Health Sciences, London, United Kingdom 2013; p. 219.  Back to cited text no. 3
    
4.
Singh M, Kaur B. Actinomycetic corneal ulcer. Eye (Lond) 1989;3(Pt 4):460-2.  Back to cited text no. 4
    
5.
Karimian F, Feizi S, Nazari R, Zarin-Bakhsh P. Delayed-onset actinomyces keratitis after laser in situ keratomileusis. Cornea 2008;27:843-6.  Back to cited text no. 5
    
6.
Lalitha P, Tiwari M, Prajna NV, Gilpin C, Prakash K, Srinivasan M, et al. Nocardia keratitis: Species, drug sensitivities, and clinical correlation. Cornea 2007;26:255-9.  Back to cited text no. 6
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]



 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
Abstract
Case Report
Discussion
References
Article Figures

 Article Access Statistics
    Viewed40    
    Printed0    
    Emailed0    
    PDF Downloaded6    
    Comments [Add]    

Recommend this journal